SYT8

Across TCGA patient cohorts, SYT8 protein abundance is significantly associated with the RNA expression of many other genes, with 710 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible SYT8-associated genes across cancer lineages are PFKFB3, SBF1, and RANGAP1. Each is linked with SYT8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYT8-to-partner and partner-to-SYT8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SYT8 versus PFKFB3 in PDAC, with a Pearson correlation of -0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYT8→partner) and Y-score (partner→SYT8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PFKFB3 →	-1.079	-1.042	.003	.009	3	2
HNSC	SBF1 →	-1.450	-0.914	.004	.002	3	1
HNSC	RANGAP1 →	-1.194	-0.914	.003	.002	3	1
HNSC	ACO2 →	-0.743	-1.143	.004	.008	3	1
HNSC	TELO2 →	-0.976	-1.043	<.001	.001	3	1
HNSC	PCIF1 →	-1.743	-1.153	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 710 associations by consensus.

SYT8 vs PFKFB3 — PDAC

Explore this scatter interactively →