SYT8

Across TCGA patient cohorts, SYT8 mutation is significantly associated with the RNA expression of many other genes, with 401 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SYT8-associated genes across cancer lineages are MTATP6P29, RPL35AP37, and RNU6-1318P. Each is linked with SYT8 in more than 3 cancer types. Because this analysis shows association rather than direction, both SYT8-to-partner and partner-to-SYT8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTATP6P29 grouped by SYT8-low versus SYT8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYT8→partner) and Y-score (partner→SYT8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MTATP6P29 →	+0.336	+3.133	<.001	.009	3	4
COAD	RPL35AP37 →	+0.492	+4.543	<.001	.005	3	2
BLCA	RNU6-1318P →	+0.361	+5.588	<.001	.004	3	2
BRCA	RNU2-47P →	+0.628	+8.055	<.001	.007	3	2
UCEC	OSBPL9P3 →	+0.118	+2.783	.002	.008	3	2
CESC	RNU6-912P →	+0.428	+5.010	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 401 associations by consensus.

MTATP6P29 by SYT8 expression — UCEC

Explore this box plot interactively →