SYT8

Across TCGA cell cohorts, SYT8 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SYT8-associated genes across cancer lineages are ALG13, SLC35F2, and MCHR1. Each is linked with SYT8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYT8-to-partner and partner-to-SYT8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ALG13 grouped by SYT8-low versus SYT8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYT8→partner) and Y-score (partner→SYT8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ALG13 →	+0.571	+3.364	.002	.002	3	1
LARGE_INTESTINE	SLC35F2 →	+0.688	+3.451	.008	.002	3	1
LARGE_INTESTINE	MCHR1 →	+0.083	+3.906	<.001	.001	3	1
LARGE_INTESTINE	FBXO32 →	-0.852	-3.278	.005	.006	3	1
LARGE_INTESTINE	ASB18 →	+0.053	+2.546	<.001	.002	3	1
LARGE_INTESTINE	OR51I2 →	+0.163	+2.266	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

ALG13 by SYT8 expression — LARGE_INTESTINE

Explore this box plot interactively →