SYT7

Across TCGA cell cohorts, SYT7 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SYT7-associated genes across cancer lineages are KRTAP10-5, ECE2, and COX6A2. Each is linked with SYT7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYT7-to-partner and partner-to-SYT7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP10-5 grouped by SYT7-low versus SYT7-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYT7→partner) and Y-score (partner→SYT7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	KRTAP10-5 →	+0.011	+4.078	<.001	.009	3	1
LARGE_INTESTINE	ECE2 →	+0.332	+4.054	<.001	.004	3	1
LARGE_INTESTINE	COX6A2 →	+0.082	+4.437	<.001	.004	3	1
LARGE_INTESTINE	TBC1D21 →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	CCER1 →	+0.013	+4.562	<.001	<.001	3	1
LARGE_INTESTINE	SPINK9 →	+0.351	+3.793	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

KRTAP10-5 by SYT7 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →