SYT7

Across TCGA pan-cancer cohorts, SYT7 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SYT7’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SYT7 RNA is repressed in tumor relative to normal tissue. In most cancer types SYT7 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and COAD are the cancer types where SYT7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SYT7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−3.360	<.001	12	view →
KIRP	Male	All	−3.353	<.001	11	view →
COAD	All	IV	+2.111	<.001	10	view →
THCA	All	II,III,IV	−1.167	<.001	10	view →
LUAD	Male	III,IV	+3.556	<.001	9	view →
BLCA	Male	III,IV	+2.555	<.001	8	view →
HNSC	Female	III,IV	+2.184	<.001	8	view →
READ	All	All	+1.723	<.001	7	view →
LUSC	Male	All	+1.494	<.001	7	view →
BRCA	All	All	+0.731	<.001	6	view →
LIHC	All	II,III,IV	−1.563	<.001	4	view →
CHOL	All	All	−2.434	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

SYT7–KIRC

Open the KIRC breakdown →