SYT4

Across TCGA patient cohorts, SYT4 mutation is significantly associated with the RNA expression of many other genes, with 4,053 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYT4-associated genes across cancer lineages are SNRPD1, DNAJC25, and SEH1L. Each is linked with SYT4 in more than 3 cancer types. Because this analysis shows association rather than direction, both SYT4-to-partner and partner-to-SYT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNRPD1 grouped by SYT4-low versus SYT4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYT4→partner) and Y-score (partner→SYT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNRPD1 →	+0.421	+1.654	<.001	.002	3	4
UCEC	DNAJC25 →	+0.602	+2.169	<.001	<.001	3	3
SKCM	SEH1L →	+0.458	+1.879	.003	.004	3	3
LUAD	SNRPFP2 →	+0.392	+2.333	<.001	.001	3	3
CESC	RNY1P1 →	+0.131	+4.020	<.001	.009	3	3
LUSC	LINC01840 →	+0.164	+3.780	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,053 associations by consensus.

SNRPD1 by SYT4 expression — UCEC

Explore this box plot interactively →