SYT4

Across TCGA pan-cancer cohorts, SYT4 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of SYT4’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SYT4 RNA is repressed in tumor relative to normal tissue. In most cancer types SYT4 is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, THCA, and KIRC are the cancer types where SYT4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SYT4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	−1.036	<.001	10	view →
THCA	All	All	−0.321	<.001	9	view →
KIRC	Male	II,III,IV	−0.128	<.001	9	view →
LUSC	All	All	−0.509	.001	7	view →
KIRP	All	All	−0.092	<.001	6	view →
LIHC	Male	All	−0.019	<.001	6	view →
READ	All	All	−1.337	<.001	5	view →
LUAD	All	II,III,IV	−0.497	.005	5	view →
STAD	Female	III,IV	−1.530	<.001	4	view →
KICH	All	All	−0.235	.005	4	view →
PRAD	All	All	−0.448	.038	2	view →
UCEC	All	All	−0.317	.020	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

SYT4–COAD

Open the COAD breakdown →