SYT4

Across TCGA cell cohorts, SYT4 mutation is significantly associated with the drug of many other genes, with 24 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SYT4-associated genes across cancer lineages are AZD7969, IAP_7638, and PLK_6522. Each is linked with SYT4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYT4-to-partner and partner-to-SYT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AZD7969 grouped by SYT4-low versus SYT4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYT4→partner) and Y-score (partner→SYT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AZD7969 →	+0.538	+2.649	.018	.046	3	1
LARGE_INTESTINE	IAP_7638 →	+0.433	+2.678	.003	.037	3	1
LARGE_INTESTINE	PLK_6522 →	+0.849	+2.649	.009	.046	3	1
LARGE_INTESTINE	IWP-2 →	+0.285	+2.893	.032	.034	3	1
LARGE_INTESTINE	GSK2801 →	+0.363	+2.649	.021	.046	3	1
LARGE_INTESTINE	GSK2256098C →	+0.394	+2.710	.009	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

AZD7969 by SYT4 expression — LARGE_INTESTINE

Explore this box plot interactively →