SYT17

Across TCGA patient cohorts, SYT17 mutation is significantly associated with the RNA expression of many other genes, with 4,411 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYT17-associated genes across cancer lineages are MIR8073, RNA5SP414, and RNU6-1217P. Each is linked with SYT17 in more than 2 cancer types. Because this analysis shows association rather than direction, both SYT17-to-partner and partner-to-SYT17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR8073 grouped by SYT17-low versus SYT17-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYT17→partner) and Y-score (partner→SYT17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MIR8073 →	+0.419	+4.433	<.001	.007	3	3
LUSC	RNA5SP414 →	+0.427	+6.102	<.001	.001	3	2
BRCA	RNU6-1217P →	+0.607	+4.556	<.001	.001	3	2
UCEC	MIR6803 →	+0.101	+3.834	<.001	.007	3	2
UCEC	MIR8087 →	+0.427	+2.047	<.001	<.001	3	2
UCEC	ACACA →	+0.535	+2.542	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,411 associations by consensus.

MIR8073 by SYT17 expression — BLCA

Explore this box plot interactively →