SYT16

Across TCGA patient cohorts, SYT16 mutation is significantly associated with the RNA expression of many other genes, with 3,840 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYT16-associated genes across cancer lineages are THAP11, RNU2-47P, and RNU6-220P. Each is linked with SYT16 in more than 3 cancer types. Because this analysis shows association rather than direction, both SYT16-to-partner and partner-to-SYT16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, THAP11 grouped by SYT16-low versus SYT16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYT16→partner) and Y-score (partner→SYT16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	THAP11 →	+0.317	+2.186	.003	<.001	3	4
LUSC	RNU2-47P →	+0.184	+5.754	<.001	<.001	3	4
SKCM	RNU6-220P →	+0.094	+2.186	<.001	.004	3	4
GBM	RNU6-548P →	+0.603	+3.581	.007	.008	3	3
LIHC	TRAJ33 →	+0.536	+5.008	<.001	.004	3	3
UCEC	BUB3 →	+0.390	+1.791	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,840 associations by consensus.

THAP11 by SYT16 expression — UCEC

Explore this box plot interactively →