Across TCGA cell cohorts, SYT15 mutation is significantly associated with the RNA expression of many other genes, with 57 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SYT15-associated genes across cancer lineages are NLRP14, KCNC2, and MRGPRX1. Each is linked with SYT15 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYT15-to-partner and partner-to-SYT15 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYT15→partner) and Y-score (partner→SYT15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NLRP14 →	+0.196	+3.409	<.001	.008	3	1
BLOOD_Leukemia	KCNC2 →	+0.115	+3.242	<.001	.007	3	1
BLOOD_Leukemia	MRGPRX1 →	+0.037	+3.786	<.001	.002	3	1
BLOOD_Leukemia	OR2D3 →	+0.066	+3.704	<.001	.001	3	1
BLOOD_Leukemia	OR2AG1 →	+0.120	+3.540	<.001	.005	3	1
BLOOD_Leukemia	TRPM3 →	+0.038	+5.032	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

Exploration

SYT15 survival (RNA) · tumor vs normal (RNA) · all SYT15 data types