Across TCGA cell cohorts, SYT15 mutation is significantly associated with the mutation status of many other genes, with 4,689 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SYT15-associated genes across cancer lineages are UBR5, NAGLU, and ZNF592. Each is linked with SYT15 in more than 3 cancer types. Because this analysis shows association rather than direction, both SYT15-to-partner and partner-to-SYT15 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYT15→partner) and Y-score (partner→SYT15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	UBR5 →	+2.762	+2.690	.005	.005	1	4
BLOOD_Leukemia	NAGLU →	+3.347	+3.472	<.001	<.001	1	4
SKIN	ZNF592 →	+4.239	+5.053	.007	.007	1	4
LARGE_INTESTINE	HIRA →	+3.597	+3.149	<.001	<.001	1	4
OVARY	PHF3 →	+3.345	+3.345	.007	.007	1	4
OVARY	BCL11A →	+4.345	+4.345	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,689 associations by consensus.

Exploration

SYT15 survival (RNA) · tumor vs normal (RNA) · all SYT15 data types