SYT14

Across TCGA cell cohorts, SYT14 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible SYT14-associated genes across cancer lineages are CABP2, CCDC105, and SPZ1. Each is linked with SYT14 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYT14-to-partner and partner-to-SYT14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CABP2 grouped by SYT14-low versus SYT14-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYT14→partner) and Y-score (partner→SYT14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CABP2 →	+0.040	+5.029	.006	.006	3	2
PANCREAS	CCDC105 →	+0.010	+4.614	<.001	.004	3	1
PANCREAS	SPZ1 →	+0.016	+4.491	<.001	.003	3	1
PANCREAS	KCNG4 →	+0.010	+4.614	<.001	.004	3	1
PANCREAS	AHSP →	+0.134	+4.011	.007	.009	3	1
PANCREAS	TRIM49B →	+0.022	+4.614	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

CABP2 by SYT14 expression — LUNG_SCLC

Explore this box plot interactively →