SYT12

Across TCGA patient cohorts, SYT12 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYT12-associated genes across cancer lineages are MEK1, p38-MAPK_pT180_Y182, and PCNA. Each is linked with SYT12 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYT12-to-partner and partner-to-SYT12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by SYT12-low versus SYT12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYT12→partner) and Y-score (partner→SYT12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.436	+3.584	.013	.002	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.461	-3.000	.033	.036	3	1
UCEC	PCNA →	+0.265	+3.169	.011	.019	2	2
UCEC	PDK1_pS241 →	+0.170	+2.321	.040	.034	3	1
UCEC	Rab25 →	-0.328	-3.169	.040	.019	3	1
UCEC	Shc_pY317 →	-0.210	-3.169	.004	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

MEK1 by SYT12 expression — UCEC

Explore this box plot interactively →