Across TCGA patient cohorts, SYS1 mutation is significantly associated with the RNA expression of many other genes, with 248 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYS1-associated genes across cancer lineages are RAB28P2, ZNF519P4, and RNU11-6P. Each is linked with SYS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYS1-to-partner and partner-to-SYS1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYS1→partner) and Y-score (partner→SYS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RAB28P2 →	+0.169	+5.039	<.001	.003	3	2
SKCM	ZNF519P4 →	+0.340	+4.282	<.001	.009	3	2
CESC	RNU11-6P →	+0.386	+5.669	<.001	.003	3	2
UCEC	ATF4P1 →	+0.051	+2.547	<.001	.009	3	2
UCEC	FDX1P2 →	+0.124	+2.631	.006	.007	3	2
SKCM	LINC02143 →	+0.052	+4.282	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 248 associations by consensus.

Exploration

SYS1 survival (RNA) · tumor vs normal (RNA) · all SYS1 data types