SYS1-DBNDD2

Across TCGA pan-cancer cohorts, SYS1-DBNDD2 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated SYS1-DBNDD2 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher SYS1-DBNDD2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SYS1-DBNDD2 expression acts as an unfavorable survival marker, although some lineages such as PAAD and CHOL show a favorable association.

UVM, PAAD, and CHOL are the cancer types where SYS1-DBNDD2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.608	0.838	.011	50	view →
PAAD	DFS	Quartile	All	0.604	0.120	.001	41	view →
CHOL	OS	Tertile	II,III,IV	0.886	0.307	.006	29	view →
BLCA	DFS	Median	All	0.367	0.602	.003	22	view →
LUSC	DFS	Median	III,IV	0.172	0.773	.004	17	view →
UCEC	DFS	Tertile	All	0.795	0.893	.003	16	view →
KIRC	DFS	Median	III,IV	0.601	0.374	.012	15	view →
KIRP	DFS	Median	All	0.978	0.778	.002	14	view →
ACC	DFS	Median	III,IV	0.498	0.166	.005	9	view →
CESC	OS	Tertile	IV	0.356	0.682	.037	6	view →
LIHC	DFS	Median	III,IV	0.472	0.230	.034	6	view →
READ	OS	Median	III,IV	0.863	0.414	.011	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

SYS1-DBNDD2–UVM (OS)

Open the UVM breakdown →