SYS1-DBNDD2

Across TCGA pan-cancer cohorts, SYS1-DBNDD2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SYS1-DBNDD2’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SYS1-DBNDD2 RNA is repressed in tumor relative to normal tissue. In most cancer types SYS1-DBNDD2 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KIRC, and KICH are the cancer types where SYS1-DBNDD2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SYS1-DBNDD2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.667	<.001	9	view →
KIRC	All	All	+0.208	<.001	8	view →
KICH	Female	All	−0.515	<.001	7	view →
BRCA	All	All	+0.199	<.001	6	view →
LIHC	All	III,IV	+0.105	.001	6	view →
LUAD	All	All	−0.124	.008	4	view →
CHOL	All	All	+0.405	<.001	3	view →
PAAD	All	All	+0.420	.049	2	view →
BLCA	All	IV	−0.355	.028	2	view →
UCEC	All	All	−0.273	.023	2	view →
LUSC	Female	III,IV	−0.255	.009	2	view →
HNSC	All	III,IV	+0.148	.040	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SYS1-DBNDD2–THCA

Open the THCA breakdown →