SYPL1

Across TCGA pan-cancer cohorts, SYPL1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SYPL1 data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SYPL1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SYPL1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

LSCC, PDAC, and HNSC are the cancer types where SYPL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	All	0.723	0.916	.008	8	view →
PDAC	OS	Median	III,IV	0.262	0.600	.034	4	view →
HNSC	OS	Quartile	All	1.000	0.935	.047	2	view →
CCRCC	DFS	Tertile	All	1.000	0.794	.045	1	view →
LUAD	OS	Quartile	II,III,IV	1.000	0.787	.037	1	view →
GBM	DFS	Median	All	0.686	0.805	.010	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SYPL1–LSCC (DFS)

Open the LSCC breakdown →