SYPL1

Across TCGA patient cohorts, SYPL1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYPL1-associated genes across cancer lineages are JNK2, Rab11, and cIAP. Each is linked with SYPL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYPL1-to-partner and partner-to-SYPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by SYPL1-low versus SYPL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYPL1→partner) and Y-score (partner→SYPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.338	+3.321	.001	.010	3	1
UCEC	Rab11 →	-0.154	-3.321	.043	.010	3	1
UCEC	cIAP →	+0.142	+2.196	.048	.034	3	1
UCEC	Ku80 →	+0.293	+2.183	.017	.035	1	1
UCEC	p27_pT198 →	+0.135	+3.321	.015	.010	1	1
UCEC	PRAS40_pT246 →	+0.239	+2.183	.007	.035	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

JNK2 by SYPL1 expression — UCEC

Explore this box plot interactively →