SYPL1

Across TCGA cell cohorts, SYPL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,056 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SYPL1-associated GO terms across cancer lineages are Nucleotide-sugar transmembrane transport, Positive regulation of monoatomic ion transport, and Protein localization to endoplasmic reticulum. Each is linked with SYPL1 in more than 10 cancer types. Because this analysis shows association rather than direction, both SYPL1-to-partner and partner-to-SYPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nucleotide-sugar transmembrane transport grouped by SYPL1-low versus SYPL1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SYPL1→partner) and Y-score (partner→SYPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Nucleotide-sugar transmembrane transport →	+0.095	+1.101	<.001	<.001	3	11
STOMACH	Positive regulation of monoatomic ion transport →	+0.113	+0.878	<.001	.004	3	9
LUNG_NSCLC_LUAD	Protein localization to endoplasmic reticulum →	+0.100	+0.608	.002	.001	3	8
SKIN	Regulation of membrane tubulation →	+0.136	+0.782	<.001	<.001	3	8
LIVER	Endoplasmic reticulum-plasma membrane tethering →	+0.252	+1.130	<.001	<.001	3	8
STOMACH	Negative regulation of actin filament polymerization →	+0.154	+1.239	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,056 associations by consensus.

Nucleotide-sugar transmembrane transport by SYPL1 expression — STOMACH

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