SYP

Across TCGA patient cohorts, SYP protein abundance is significantly associated with the RNA expression of many other genes, with 8,280 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SYP-associated genes across cancer lineages are SNAP25, CHRNB2, and TES. Each is linked with SYP in more than 3 cancer types. Because this analysis shows association rather than direction, both SYP-to-partner and partner-to-SYP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SYP versus SNAP25 in GBM, with a Pearson correlation of 0.78.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYP→partner) and Y-score (partner→SYP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SNAP25 →	+2.391	+1.253	<.001	<.001	3	4
BRCA	CHRNB2 →	+1.398	+1.399	<.001	.001	3	4
BRCA	TES →	-0.871	-1.447	.004	.001	3	4
GBM	MYT1 →	+1.498	+0.613	<.001	<.001	3	4
BRCA	BEX1 →	+2.559	+1.221	.001	.003	3	4
GBM	WDR17 →	+0.723	+0.984	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,280 associations by consensus.

SYP vs SNAP25 — GBM

Explore this scatter interactively →