SYP-AS1

Across TCGA pan-cancer cohorts, SYP-AS1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SYP-AS1 data layer.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher SYP-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SYP-AS1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and PAAD show a favorable association.

COAD, BRCA, and SKCM are the cancer types where SYP-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	II,III,IV	0.239	0.511	<.001	57	view →
BRCA	DFS	Tertile	All	0.570	1.000	.033	54	view →
SKCM	DFS	Tertile	IV	0.785	0.138	.006	47	view →
THCA	OS	Tertile	III,IV	0.788	0.956	.002	45	view →
KIRC	OS	Tertile	All	0.479	0.660	.001	42	view →
KIRP	DFS	Tertile	III,IV	0.098	0.507	.003	41	view →
ACC	DFS	Median	II,III,IV	0.137	0.655	.001	35	view →
LAML	DFS	Median	All	0.331	0.538	.003	34	view →
PAAD	OS	Tertile	All	0.776	0.445	.011	33	view →
LUSC	OS	Median	All	0.742	0.608	.003	21	view →
THYM	OS	Median	All	1.000	0.662	.006	19	view →
KICH	OS	Tertile	III,IV	0.178	0.847	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SYP-AS1–COAD (DFS)

Open the COAD breakdown →