SYNPR

Across TCGA patient cohorts, SYNPR RNA expression is significantly associated with the protein abundance of many other proteins, with 19,879 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SYNPR-associated proteins across cancer lineages are SP100, TBC1D2B_S155, and SKAP2. Each is linked with SYNPR in more than 4 cancer types. Because this analysis shows association rather than direction, both SYNPR-to-partner and partner-to-SYNPR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SYNPR versus SP100 in GBM, with a Pearson correlation of -0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNPR→partner) and Y-score (partner→SYNPR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SP100 →	-0.493	-1.291	<.001	<.001	3	5
LSCC	TBC1D2B_S155 →	-0.443	-0.404	<.001	<.001	3	5
GBM	SKAP2 →	-0.606	-1.016	<.001	.002	3	5
HNSC	UPP1 →	-1.120	-0.569	<.001	<.001	3	4
HNSC	PYGL →	-0.718	-0.511	<.001	<.001	3	4
HNSC	TRIM2_T371 →	+1.155	+0.560	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,879 associations by consensus.

SYNPR vs SP100 — GBM

Explore this scatter interactively →