SYNPR-AS1

Across TCGA pan-cancer cohorts, SYNPR-AS1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated SYNPR-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SYNPR-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SYNPR-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and BRCA show a favorable association.

KIRC, KICH, and LUAD are the cancer types where SYNPR-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.792	0.889	<.001	126	view →
KICH	DFS	Tertile	All	0.025	0.904	<.001	108	view →
LUAD	DFS	Median	All	0.850	0.731	<.001	78	view →
BRCA	OS	Tertile	III,IV	0.885	0.716	.001	52	view →
UCS	DFS	Median	II,III,IV	0.468	0.157	.006	50	view →
COAD	OS	Quartile	All	0.693	0.284	.001	44	view →
UVM	OS	Tertile	All	0.869	0.503	.004	32	view →
HNSC	OS	Median	All	0.221	0.501	.003	31	view →
THCA	DFS	Median	All	0.908	0.954	.010	26	view →
CHOL	DFS	Tertile	All	0.689	0.142	.003	15	view →
LIHC	DFS	Tertile	II,III,IV	0.241	0.437	.022	9	view →
STAD	OS	Tertile	II,III,IV	0.398	0.710	.025	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

SYNPR-AS1–KIRC (OS)

Open the KIRC breakdown →