SYNPR-AS1

Across TCGA pan-cancer cohorts, SYNPR-AS1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SYNPR-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SYNPR-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SYNPR-AS1 is over-expressed in tumor, although a few such as KICH and LIHC show the opposite, repressed pattern.

COAD, LUAD, and BRCA are the cancer types where SYNPR-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SYNPR-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	+0.927	<.001	10	view →
LUAD	Female	All	+1.068	<.001	7	view →
BRCA	Female	II,III,IV	+0.698	<.001	6	view →
HNSC	Male	III,IV	+0.698	.024	4	view →
PAAD	All	All	+1.682	.003	2	view →
READ	Female	All	+1.266	.011	2	view →
STAD	Male	All	+0.806	.016	2	view →
LUSC	All	All	+0.406	.020	2	view →
THCA	All	All	+0.337	.001	2	view →
PRAD	All	All	+0.309	.042	2	view →
KICH	All	All	−0.063	.016	2	view →
CHOL	All	All	+1.197	.009	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SYNPR-AS1–COAD

Open the COAD breakdown →