SYNPO2L

Across TCGA patient cohorts, SYNPO2L mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYNPO2L-associated genes across cancer lineages are MEK1, Notch1, and PCNA. Each is linked with SYNPO2L in more than 1 cancer types. Because this analysis shows association rather than direction, both SYNPO2L-to-partner and partner-to-SYNPO2L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by SYNPO2L-low versus SYNPO2L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNPO2L→partner) and Y-score (partner→SYNPO2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.237	+1.459	.024	.011	3	2
UCEC	Notch1 →	+0.095	+1.428	.019	.025	3	2
UCEC	PCNA →	+0.167	+1.169	.007	.017	3	2
UCEC	Rad50 →	-0.178	-1.765	.010	.013	3	2
UCEC	Annexin-1 →	+0.409	+2.107	.006	.002	3	2
UCEC	S6_pS240_S244 →	+0.306	+1.925	.008	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

MEK1 by SYNPO2L expression — UCEC

Explore this box plot interactively →