SYNPO2L

Across TCGA pan-cancer cohorts, SYNPO2L RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of SYNPO2L’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SYNPO2L RNA is repressed in tumor relative to normal tissue. In most cancer types SYNPO2L is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

LUAD, LUSC, and KICH are the cancer types where SYNPO2L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SYNPO2L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	All	−0.851	<.001	8	view →
LUSC	All	All	−0.632	<.001	6	view →
KICH	All	All	−0.112	<.001	6	view →
HNSC	Male	All	−1.624	.006	5	view →
READ	All	II,III,IV	+0.160	.018	4	view →
KIRC	Male	II,III,IV	−0.050	.002	4	view →
CHOL	All	All	+0.068	<.001	3	view →
BLCA	Male	All	+0.089	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

SYNPO2L–LUAD

Open the LUAD breakdown →