SYNPO2L

Across TCGA cell cohorts, SYNPO2L mutation is significantly associated with the RNA expression of many other genes, with 1,386 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SYNPO2L-associated genes across cancer lineages are NCS1, ZNF346, and ATG4C. Each is linked with SYNPO2L in more than 1 cancer types. Because this analysis shows association rather than direction, both SYNPO2L-to-partner and partner-to-SYNPO2L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NCS1 grouped by SYNPO2L-low versus SYNPO2L-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNPO2L→partner) and Y-score (partner→SYNPO2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NCS1 →	+0.842	+3.459	.003	.001	3	2
LARGE_INTESTINE	ZNF346 →	+0.506	+3.169	.009	.006	3	2
LARGE_INTESTINE	ATG4C →	+0.596	+3.321	<.001	.002	3	2
LARGE_INTESTINE	RAB19 →	+0.691	+2.158	.004	.004	3	2
LARGE_INTESTINE	ECI1 →	+0.554	+2.850	.005	<.001	3	2
LARGE_INTESTINE	THAP9 →	+0.453	+2.158	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,386 associations by consensus.

NCS1 by SYNPO2L expression — LARGE_INTESTINE

Explore this box plot interactively →