SYNPO2

Across TCGA patient cohorts, SYNPO2 protein abundance is significantly associated with the RNA expression of many other genes, with 16,763 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SYNPO2-associated genes across cancer lineages are SEPTIN4, MGP, and C7. Each is linked with SYNPO2 in more than 9 cancer types. Because this analysis shows association rather than direction, both SYNPO2-to-partner and partner-to-SYNPO2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SYNPO2 versus SEPTIN4 in GBM, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNPO2→partner) and Y-score (partner→SYNPO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SEPTIN4 →	+1.059	+0.595	<.001	<.001	3	10
COAD	MGP →	+1.703	+0.682	<.001	<.001	3	10
CCRCC	C7 →	+3.070	+1.050	<.001	<.001	3	10
BRCA	AOC3 →	+1.454	+0.614	<.001	<.001	3	10
COAD	LYVE1 →	+1.243	+0.684	<.001	<.001	3	10
PDAC	ABCA9 →	+1.040	+0.518	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,763 associations by consensus.

SYNPO2 vs SEPTIN4 — GBM

Explore this scatter interactively →