SYNPO2

Across TCGA patient cohorts, SYNPO2 mutation is significantly associated with the RNA expression of many other genes, with 6,777 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYNPO2-associated genes across cancer lineages are COQ2, PSMC3IP, and RAD51. Each is linked with SYNPO2 in more than 5 cancer types. Because this analysis shows association rather than direction, both SYNPO2-to-partner and partner-to-SYNPO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COQ2 grouped by SYNPO2-low versus SYNPO2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNPO2→partner) and Y-score (partner→SYNPO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	COQ2 →	+0.541	+3.840	<.001	<.001	3	6
UCEC	PSMC3IP →	+0.742	+2.233	<.001	<.001	3	5
UCEC	RAD51 →	+0.887	+2.662	<.001	<.001	3	5
UCEC	COQ3 →	+0.383	+1.558	<.001	<.001	3	5
UCEC	OXSR1 →	+0.294	+1.273	.004	.008	3	5
UCEC	FAM136A →	+0.438	+1.412	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,777 associations by consensus.

COQ2 by SYNPO2 expression — STAD

Explore this box plot interactively →