SYNPO2

Across TCGA patient cohorts, SYNPO2 mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYNPO2-associated genes across cancer lineages are ASNS, PDCD4, and Cyclin-B1. Each is linked with SYNPO2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SYNPO2-to-partner and partner-to-SYNPO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by SYNPO2-low versus SYNPO2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNPO2→partner) and Y-score (partner→SYNPO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.622	+3.321	<.001	.009	3	4
STAD	PDCD4 →	-0.432	-3.169	.020	.018	3	3
UCEC	Cyclin-B1 →	+0.556	+1.736	<.001	<.001	3	3
COAD	FASN →	+0.470	+2.321	.002	.033	3	3
COAD	p90 RSK →	+0.265	+2.708	.012	.003	3	3
UCEC	ATM →	-0.338	-1.794	.009	.024	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

ASNS by SYNPO2 expression — COAD

Explore this box plot interactively →