SYNPO2

Across TCGA cell cohorts, SYNPO2 mutation is significantly associated with the RNA expression of many other genes, with 287 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SYNPO2-associated genes across cancer lineages are MINAR2, MFSD2A, and FAM71C. Each is linked with SYNPO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYNPO2-to-partner and partner-to-SYNPO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MINAR2 grouped by SYNPO2-low versus SYNPO2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNPO2→partner) and Y-score (partner→SYNPO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MINAR2 →	+0.004	+3.040	<.001	.002	3	2
BLOOD_Leukemia	MFSD2A →	+1.149	+3.459	.002	.002	3	2
SKIN	FAM71C →	+0.017	+4.095	<.001	.009	3	2
PANCREAS	KRTAP5-3 →	+0.035	+5.000	<.001	.006	3	1
URINARY_TRACT	KRTAP2-1 →	+0.100	+4.087	<.001	.009	3	1
URINARY_TRACT	KRTAP4-12 →	+0.233	+4.217	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 287 associations by consensus.

MINAR2 by SYNPO2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →