SYNM

Across TCGA pan-cancer cohorts, SYNM Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SYNM data layer compared with 24 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher SYNM Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SYNM expression acts as an unfavorable survival marker, although some lineages such as UCEC and GBM show a favorable association.

KICH, UCEC, and HNSC are the cancer types where SYNM Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	All	0.025	0.904	<.001	36	view →
UCEC	OS	Median	II,III,IV	0.941	0.454	.013	20	view →
HNSC	OS	Median	All	0.164	0.687	.001	7	view →
SKCM	OS	Median	III,IV	0.353	0.729	.043	3	view →
GBM	DFS	Median	All	1.000	0.248	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SYNM–KICH (DFS)

Open the KICH breakdown →