SYNM

Across TCGA pan-cancer cohorts, SYNM RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SYNM’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where SYNM RNA is repressed in tumor relative to normal tissue. In most cancer types SYNM is over-expressed in tumor, although a few such as BLCA and THCA show the opposite, repressed pattern.

BLCA, THCA, and KIRC are the cancer types where SYNM tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SYNM RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−7.222	<.001	11	view →
THCA	All	IV	−2.564	<.001	11	view →
KIRC	Female	III,IV	+1.557	<.001	11	view →
COAD	Male	II,III,IV	−3.671	<.001	10	view →
LUAD	Female	III,IV	−2.093	<.001	8	view →
LUSC	Female	All	−1.527	<.001	8	view →
LIHC	Female	All	+0.978	<.001	7	view →
BRCA	All	III,IV	−4.121	<.001	6	view →
UCEC	All	III,IV	−3.791	<.001	6	view →
HNSC	Male	All	−1.345	.004	6	view →
STAD	Female	All	−4.907	<.001	5	view →
READ	All	All	−4.312	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

SYNM–BLCA

Open the BLCA breakdown →