SYNM

Across TCGA patient cohorts, SYNM protein abundance is significantly associated with the RNA expression of many other genes, with 11,155 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SYNM-associated genes across cancer lineages are RHOJ, SPARCL1, and JAM2. Each is linked with SYNM in more than 8 cancer types. Because this analysis shows association rather than direction, both SYNM-to-partner and partner-to-SYNM results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SYNM versus RHOJ in LUAD, with a Pearson correlation of 0.53.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNM→partner) and Y-score (partner→SYNM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RHOJ →	+0.757	+0.446	<.001	<.001	3	9
COAD	SPARCL1 →	+1.382	+0.895	<.001	<.001	3	9
UCEC	JAM2 →	+0.805	+0.785	<.001	<.001	3	9
OV	LHFPL6 →	+1.059	+0.473	<.001	<.001	3	9
HNSC	RASGRP2 →	+0.769	+0.785	<.001	<.001	3	9
GBM	SRPX →	+1.524	+0.765	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,155 associations by consensus.

SYNM vs RHOJ — LUAD

Explore this scatter interactively →