SYNM

Across TCGA patient cohorts, SYNM mutation is significantly associated with the RNA expression of many other genes, with 4,472 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYNM-associated genes across cancer lineages are PYGL, VPS18, and HNRNPA1P65. Each is linked with SYNM in more than 2 cancer types. Because this analysis shows association rather than direction, both SYNM-to-partner and partner-to-SYNM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PYGL grouped by SYNM-low versus SYNM-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNM→partner) and Y-score (partner→SYNM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PYGL →	+1.412	+2.228	.003	.006	3	3
UCEC	VPS18 →	+0.508	+1.509	<.001	<.001	3	3
STAD	HNRNPA1P65 →	+0.189	+3.316	<.001	.009	3	3
READ	COX6CP7 →	+0.192	+4.421	<.001	.009	3	3
READ	ATF4P2 →	+0.056	+5.179	.005	.001	3	3
UCEC	MAP1LC3B2 →	+0.196	+1.098	.009	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,472 associations by consensus.

PYGL by SYNM expression — SKCM

Explore this box plot interactively →