SYNM

Across TCGA cell cohorts, SYNM mutation is significantly associated with the RNA expression of many other genes, with 1,152 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SYNM-associated genes across cancer lineages are ARHGAP19, F11, and PMM1. Each is linked with SYNM in more than 2 cancer types. Because this analysis shows association rather than direction, both SYNM-to-partner and partner-to-SYNM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARHGAP19 grouped by SYNM-low versus SYNM-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNM→partner) and Y-score (partner→SYNM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ARHGAP19 →	+0.574	+2.628	.009	.002	3	3
CNS	F11 →	+0.068	+4.201	<.001	.003	3	2
BLOOD_Leukemia	PMM1 →	+0.780	+2.489	.001	.007	3	2
BLOOD_Leukemia	NEIL3 →	+1.194	+2.489	.001	.007	3	2
BLOOD_Leukemia	NTN5 →	+0.648	+3.733	<.001	<.001	3	2
BLOOD_Leukemia	CCSAP →	+0.851	+3.228	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,152 associations by consensus.

ARHGAP19 by SYNM expression — LARGE_INTESTINE

Explore this box plot interactively →