SYNJ2-IT1

Across TCGA pan-cancer cohorts, SYNJ2-IT1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated SYNJ2-IT1 data layer.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher SYNJ2-IT1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SYNJ2-IT1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SARC show a favorable association.

READ, KIRC, and COAD are the cancer types where SYNJ2-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Tertile	III,IV	0.254	0.705	<.001	114	view →
KIRC	OS	Quartile	All	0.526	0.686	<.001	81	view →
COAD	DFS	Median	III,IV	0.411	0.753	<.001	46	view →
DLBC	OS	Quartile	II,III,IV	0.257	1.000	.001	29	view →
SKCM	DFS	Tertile	IV	0.016	0.541	.008	21	view →
UCS	DFS	Tertile	II,III,IV	0.184	0.490	.012	18	view →
MESO	DFS	Tertile	IV	0.130	0.405	.019	18	view →
TGCT	OS	Tertile	All	0.920	0.992	.019	18	view →
THCA	OS	Tertile	IV	0.877	1.000	.011	18	view →
BRCA	DFS	Quartile	All	0.350	0.589	.009	17	view →
LUAD	OS	Quartile	All	0.199	0.382	.013	14	view →
LGG	DFS	Tertile	All	0.623	0.756	.021	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

SYNJ2-IT1–READ (OS)

Open the READ breakdown →