SYNJ2-IT1

Across TCGA pan-cancer cohorts, SYNJ2-IT1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of SYNJ2-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SYNJ2-IT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SYNJ2-IT1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, COAD, and THCA are the cancer types where SYNJ2-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SYNJ2-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.074	.010	5	view →
COAD	All	All	+0.124	.012	4	view →
THCA	Female	All	−0.061	.004	3	view →
PRAD	All	All	+0.212	.001	2	view →
LUSC	All	II,III,IV	+0.070	.043	2	view →
THCA	All	IV	+0.102	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 5 lineages.

SYNJ2-IT1–HNSC

Open the HNSC breakdown →