SYNJ1

Across TCGA patient cohorts, SYNJ1 mutation is significantly associated with the RNA expression of many other genes, with 4,011 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYNJ1-associated genes across cancer lineages are UHRF1, BAG3, and MPPE1. Each is linked with SYNJ1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SYNJ1-to-partner and partner-to-SYNJ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UHRF1 grouped by SYNJ1-low versus SYNJ1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNJ1→partner) and Y-score (partner→SYNJ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UHRF1 →	+0.576	+1.373	<.001	.001	3	3
UCEC	BAG3 →	+0.420	+1.716	<.001	.002	3	3
UCEC	MPPE1 →	+0.383	+1.696	<.001	<.001	3	3
UCEC	EME1 →	+0.475	+1.519	<.001	<.001	3	3
UCEC	PES1 →	+0.349	+1.222	.001	.004	3	3
UCEC	PPP6R2 →	+0.257	+3.413	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,011 associations by consensus.

UHRF1 by SYNJ1 expression — UCEC

Explore this box plot interactively →