SYNJ1

Across TCGA pan-cancer cohorts, SYNJ1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated SYNJ1 data layer compared with 3 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SYNJ1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SYNJ1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

HNSC, KIRC, and ACC are the cancer types where SYNJ1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.779	0.639	<.001	87	view →
KIRC	OS	Quartile	All	0.752	0.555	<.001	78	view →
ACC	DFS	Tertile	All	0.499	0.858	<.001	30	view →
MESO	OS	Median	IV	0.344	0.811	.004	30	view →
BLCA	DFS	Tertile	All	0.190	0.508	.006	12	view →
PAAD	OS	Quartile	All	0.705	0.452	.013	11	view →
UVM	DFS	Tertile	III,IV	0.253	0.699	.035	10	view →
PRAD	OS	Tertile	All	0.808	0.954	.004	10	view →
KICH	OS	Quartile	All	0.723	1.000	.015	8	view →
CHOL	DFS	Tertile	All	1.000	0.253	.036	6	view →
LUAD	DFS	Median	IV	0.745	0.254	.010	6	view →
SARC	OS	Tertile	All	0.843	0.647	.016	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

SYNJ1–HNSC (DFS)

Open the HNSC breakdown →