SYNJ1

Across TCGA patient cohorts, SYNJ1 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYNJ1-associated genes across cancer lineages are ATM, eEF2, and Ku80. Each is linked with SYNJ1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SYNJ1-to-partner and partner-to-SYNJ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SYNJ1-low versus SYNJ1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNJ1→partner) and Y-score (partner→SYNJ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.598	-2.044	<.001	<.001	3	3
UCEC	eEF2 →	+0.267	+1.999	.007	.008	3	2
LUSC	Ku80 →	+0.373	+2.197	.020	.033	3	2
UCEC	EGFR_pY1068 →	-0.227	-1.632	.001	<.001	3	2
UCEC	ERK2 →	+0.116	+1.321	.032	.027	3	2
SKCM	FoxM1 →	+0.211	+1.700	.014	.043	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

ATM by SYNJ1 expression — UCEC

Explore this box plot interactively →