SYNJ1

Across TCGA cell cohorts, SYNJ1 mutation is significantly associated with the RNA expression of many other genes, with 497 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SYNJ1-associated genes across cancer lineages are OR2AJ1, FAM160A1, and NAA38. Each is linked with SYNJ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYNJ1-to-partner and partner-to-SYNJ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2AJ1 grouped by SYNJ1-low versus SYNJ1-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNJ1→partner) and Y-score (partner→SYNJ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	OR2AJ1 →	+0.013	+4.807	<.001	.006	3	2
LARGE_INTESTINE	FAM160A1 →	+0.926	+3.125	<.001	.008	3	2
LARGE_INTESTINE	NAA38 →	+1.112	+3.502	<.001	.001	3	2
LARGE_INTESTINE	ACTR6 →	+0.519	+2.451	.008	.009	3	2
URINARY_TRACT	NEUROD4 →	+0.147	+4.087	.002	.009	3	1
URINARY_TRACT	OR1L4 →	+0.060	+4.087	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 497 associations by consensus.

OR2AJ1 by SYNJ1 expression — BLOOD_Myeloma

Explore this box plot interactively →