SYNGR3

Across TCGA patient cohorts, SYNGR3 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYNGR3-associated genes across cancer lineages are MIR4734, MIR6781, and MIRLET7F1. Each is linked with SYNGR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYNGR3-to-partner and partner-to-SYNGR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4734 grouped by SYNGR3-low versus SYNGR3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNGR3→partner) and Y-score (partner→SYNGR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR4734 →	+0.510	+3.809	.003	.007	3	1
UCEC	MIR6781 →	+0.870	+4.043	.004	.005	3	1
UCEC	MIRLET7F1 →	+0.584	+4.764	.005	.001	3	1
UCEC	RNA5SP443 →	+0.546	+4.223	<.001	.003	3	1
UCEC	RPL23AP4 →	+0.148	+4.302	<.001	.002	3	1
UCEC	RN7SKP167 →	+0.262	+4.868	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

MIR4734 by SYNGR3 expression — UCEC

Explore this box plot interactively →