SYNGR2

Across TCGA patient cohorts, SYNGR2 mutation is significantly associated with the RNA expression of many other genes, with 248 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYNGR2-associated genes across cancer lineages are RNU6-1318P, OR11H12, and DUX4L47. Each is linked with SYNGR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYNGR2-to-partner and partner-to-SYNGR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1318P grouped by SYNGR2-low versus SYNGR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNGR2→partner) and Y-score (partner→SYNGR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-1318P →	+0.426	+3.358	<.001	.001	3	2
SKCM	OR11H12 →	+0.077	+6.199	<.001	.001	3	1
SKCM	DUX4L47 →	+0.133	+5.867	<.001	.003	3	1
SKCM	RN7SL498P →	+0.168	+5.097	<.001	.008	3	1
BLCA	GUCA1C →	+0.283	+3.193	.002	.006	3	1
BLCA	TSPY2 →	+0.672	+3.435	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 248 associations by consensus.

RNU6-1318P by SYNGR2 expression — UCEC

Explore this box plot interactively →