SYNGAP1-AS1

Across TCGA pan-cancer cohorts, SYNGAP1-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated SYNGAP1-AS1 data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher SYNGAP1-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SYNGAP1-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and OV show a favorable association.

UCS, ACC, and KIRC are the cancer types where SYNGAP1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Tertile	II,III,IV	0.710	0.241	<.001	108	view →
ACC	DFS	Median	All	0.414	0.736	<.001	74	view →
KIRC	OS	Tertile	All	0.489	0.689	<.001	34	view →
LIHC	DFS	Median	All	0.359	0.493	.002	33	view →
OV	OS	Quartile	All	0.779	0.671	.010	24	view →
SARC	DFS	Tertile	All	0.169	0.467	<.001	23	view →
SKCM	DFS	Quartile	III,IV	0.595	0.273	<.001	21	view →
HNSC	OS	Quartile	All	0.398	0.662	.004	21	view →
KICH	DFS	Tertile	II,III,IV	0.634	1.000	.024	18	view →
UVM	OS	Quartile	All	0.986	0.797	.011	16	view →
BLCA	OS	Quartile	III,IV	0.431	0.717	.012	16	view →
MESO	OS	Median	III,IV	0.299	0.715	.011	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

SYNGAP1-AS1–UCS (DFS)

Open the UCS breakdown →