SYNGAP1-AS1

Across TCGA pan-cancer cohorts, SYNGAP1-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of SYNGAP1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SYNGAP1-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types SYNGAP1-AS1 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, HNSC, and LIHC are the cancer types where SYNGAP1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SYNGAP1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	−0.099	<.001	11	view →
HNSC	Male	III,IV	+0.100	.004	7	view →
LIHC	All	All	+0.065	<.001	7	view →
LUSC	All	All	+0.196	<.001	6	view →
KICH	All	All	−0.227	<.001	4	view →
LUAD	All	All	+0.132	.005	4	view →
COAD	Male	All	+0.161	.002	3	view →
CHOL	All	All	+0.370	.007	2	view →
PRAD	All	All	−0.158	<.001	2	view →
STAD	Male	All	+0.151	.037	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

SYNGAP1-AS1–KIRC

Open the KIRC breakdown →