SYNE1-AS1

Across TCGA pan-cancer cohorts, SYNE1-AS1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated SYNE1-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SYNE1-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SYNE1-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LGG show a favorable association.

KIRC, LGG, and STAD are the cancer types where SYNE1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.866	0.683	.001	52	view →
LGG	DFS	Median	All	0.468	0.320	<.001	47	view →
STAD	OS	Quartile	II,III,IV	0.347	0.609	.003	30	view →
CHOL	DFS	Tertile	II,III,IV	0.807	0.136	.008	30	view →
CESC	DFS	Tertile	III,IV	0.245	0.651	.011	24	view →
THYM	OS	Tertile	III,IV	0.212	1.000	.014	21	view →
KIRP	DFS	Quartile	All	0.876	0.368	.003	20	view →
TGCT	DFS	Tertile	All	0.450	0.744	.005	18	view →
ESCA	DFS	Quartile	III,IV	0.646	0.273	.014	12	view →
UCS	DFS	Median	All	0.641	0.405	.017	10	view →
READ	OS	Tertile	III,IV	0.676	0.923	.036	9	view →
BRCA	DFS	Tertile	IV	0.939	0.516	.013	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

SYNE1-AS1–KIRC (DFS)

Open the KIRC breakdown →