SYNE1-AS1

Across TCGA pan-cancer cohorts, SYNE1-AS1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of SYNE1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SYNE1-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types SYNE1-AS1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and LUSC are the cancer types where SYNE1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SYNE1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	−1.535	<.001	11	view →
KICH	Female	II,III,IV	−0.955	<.001	10	view →
LUSC	All	III,IV	−0.630	<.001	8	view →
BLCA	All	All	−0.439	.002	8	view →
KIRC	Male	All	−0.339	<.001	8	view →
BRCA	All	III,IV	−0.495	<.001	6	view →
UCEC	All	All	−0.388	<.001	6	view →
LUAD	All	All	−0.191	.014	3	view →
KIRP	Male	All	−0.302	.008	2	view →
READ	Female	All	−0.231	<.001	2	view →
PRAD	All	All	−0.169	<.001	2	view →
ESCA	All	All	−0.148	.020	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

SYNE1-AS1–THCA

Open the THCA breakdown →