SYNDIG1

Across TCGA pan-cancer cohorts, SYNDIG1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SYNDIG1 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher SYNDIG1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SYNDIG1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCEC show a favorable association.

ESCA, BLCA, and GBM are the cancer types where SYNDIG1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.465	0.709	.025	21	view →
BLCA	DFS	Median	All	1.000	0.326	.019	14	view →
GBM	OS	Median	All	0.089	0.413	.015	6	view →
SARC	DFS	Median	All	0.179	0.612	.024	6	view →
UCEC	DFS	Median	III,IV	0.906	0.535	.047	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SYNDIG1–ESCA (OS)

Open the ESCA breakdown →